Kǔ Qié (Bitter Nightshade) is a traditional Chinese medicinal material. It is the whole herb of Solanum dulcamara L., a plant belonging to the family Solanaceae. It is recorded in Guoyao de Yaolixue (Pharmacology of Chinese Medicines).

Efficacy & Actions

Dispels wind and dampness, clears heat and removes toxicity.

Indications

Rheumatic pain, tetanus, carbuncles and abscesses, malignant sores, scabies, and traumatic bleeding.

Modern Pharmacology

Antibacterial effect: Ku Qie exhibits certain antibacterial activity. Antitumor effect: β‑Ku Qie alkaloid has been shown to inhibit sarcoma‑180 in mice. Antibacterial, anti‑inflammatory, analgesic, and antipyretic effects: Ku Qie contains alkaloids, flavonoids, and other components, exhibiting antibacterial, anti‑inflammatory, analgesic, and antipyretic effects. Antioxidant and antitumor effects. Diuretic and anti‑edema effects: According to Guoyao de Yaolixue (Pharmacology of Chinese Medicines), it is recorded as a diuretic, as well as a remedy for neuralgia and reducing swelling.

Ingredients

Ku Qie alkaloids: α-, β-, γ1-, γ2-, and δ-kuqie alkaloids. Solasonine. Solamargine. Shu Yang Quan alkaloid. Tomatidenol. Solasodine.

Usage & Dosage

For oral administration: decoct in water, 15–30 g; or 3–10 g; or grind into powder, 1–3 g each time. For topical application: appropriate amount, fresh leaves mashed for application; or the whole herb ground into powder and sprinkled on.

Contraindications

Use with caution in patients with Spleen‑Stomach deficiency‑cold. This herb is toxic; internal use should be undertaken with caution. Excessive dosage should be avoided.

Selected Formulas

For rheumatic overstrain (Guizhou Herbal Medicine) Take 90g of Pai Feng Teng (Solanum dulcamara, also called Ku Qie), soak in 500g of wine, and drink. For hemiplegia (Guizhou Herbal Medicine) Take 60–120g of Pai Feng Teng, decoct in water and wash the whole body. Additionally, grind the leaves of Pai Feng Teng into powder, take 3g each time with wine. For unruptured back carbuncle with chills and fever (Shengji Zonglu, Ku Qie San) Take 1 liang each of Ku Qie seeds and honey-fried Gancao (Licorice). Grind into fine powder. Take 2 qian each time, mixed with licorice decoction.

Medicinal Parts

Dried whole herb. The fruit is also used medicinally.

Selection & Storage

Store in a cool, dry place, protected from moisture and insects.